DNA diagnostics for a predisposition to celiac disease (gluten intolerance)
A genetic predisposition to celiac disease is determined by the presence of the haplotype DQB1*02:01; DQA1*05:01 (*02:01) or DQB1*03:02; and DQA1*03 in the genome. Genetic testing allows excluding the diagnosis of celiac disease or identifying an existing predisposition to this pathology. The trigger of celiac disease is the intake of a number of cereal proteins with food. The inability of human gastrointestinal enzymes to digest cereal proteins leads to the formation of gliadin peptides. These are HLA-DQ2 and HLA-DQ8 molecules that have a high affinity with gliadin peptides and present them to immune cells.