DNA diagnostics for a predisposition to hypercholesterolemia

Hypercholesterolemia is an increased cholesterol level.

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High cholesterol

Hypercholesterolemia (increased cholesterol) is a fairly common genetic disorder (affecting 1 in 200 people worldwide). Increased cholesterol is one of the main risk factors of a myocardial infarction, a stroke, and a coronary heart disease. There are known gene variants that lead to lipid metabolism disorders. As a result, the synthesis and transport of lipoproteins, as well as their subsequent binding and utilization in the body, are disrupted. As a result, lipoproteins are not absorbed by cells, remain in plasma and cause the development of atherosclerosis.

Symptoms & Dangers

Symptoms of the disease depend on the location of atherosclerosis. Lesions of coronary arteries cause pain in the left half of the chest, heart rhythm disturbances (complaints of irregular, sharply increased heartbeats or a feeling of “a sinking heart”, “heart palpitations”) and the shortness of breath. Where the atherosclerotic process is localized mainly in brain vessels, headache and dizziness complaints and the appearance of “ringing in the ears” and “noise in the head” predominate. The development of atherosclerosis of lower extremity arteries leads to pain in your legs when walking, and in severe cases, pain in the lower extremities at night and in the horizontal position of a patient. Many patients with increased cholesterol levels in blood may have no complaints until atherosclerotic processes have developed sufficiently.

How will a genetic passport help?

Genetic testing makes it possible to identify genetic markers associated with increased cholesterol levels so that preventive or therapeutic measures can be taken in the event of a hypercholesterolemia risk. It is also important to identify genetic risk factors of eating disorders that influence, in great variety of ways, the consumption of more fat in your daily diet. Such risks can only be identified using a genetic test. This will help you to understand what lifestyle and dietary changes will produce the best effect and provide drug correction recommendations for hypercholesterolemia.

Genetic testing fees

FULL

177 ^BYN

Testing of 6 genes predisposing to hypercholesterolemia
Professor’s conclusion

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Offer a chance for genetic testing!!!. A gift certificate is a great and valuable thing!!! For more details, please contact us by phone.

FAQs

Is special preparation required before providing test material?

No, it is not necessary. There is no need to follow a diet or perform any other special actions before providing material for testing. Taking medications, alcohol etc. will not affect genetic testing results either.

How soon will test results be ready?

Up to 35 working days from the date of signing an agreement. In fact, much sooner: 2-3 weeks.

What do I need to have with me to submit material for testing?

You should have your passport and money on you. Minors must be accompanied by an adult.

What are your working hours?

Our working hours for clients with a booked appointment and providing test results.
On working days: Monday ‒ Thursday, from 9:00 till 17:30; on Fridays: from 9:00 till 16:30.
Days off: Saturday & Sunday.

What biological material is collected for testing and how?

For testing, buccal epithelium (epithelium of the inner part of your cheeks) is collected with a special cotton swab. It is done by a client himself or herself in the presence of a laboratory diagnostics doctor. Blood is not collected.

Can I send biological material for testing by post?

Yes, it is possible. Please follow the link for detailed instructions. The test results can be received in hard copy by mail to your home directly. Where DNA cannot be isolated from the sample provided, you will need to reimburse the cost of the reagents used.

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Accreditation

The Certificate of Conformity to STB ISO 9001-2015 No. BY/112 05.01. 077.01 00132 valid till December 3, 2026

License

License of the Ministry of Health of the Republic of Belarus for the right to provide medical services of June 17, 2011, No. 02040/6875

Certificate

Certificate of the Reference Institute for Bioanalytics, Bonn, Germany (Referenzinstitut für Bioanalytik, Bonn, Deutschland) issued on April 3, 2021

Functions of the studied genes

LDLR (7TA,8TA,10TA,11TA) low density lipoprotein receptor
39.00 BYN
It regulates the concentration of cholesterol from blood plasma. Low-density lipoprotein is the main representative of the class of plasma lipoproteins that carry cholesterol; its excess is one of the main risk factors of atherosclerosis. Alleles 8TA and 11TA — myocardial infarction risk.

PPARA (G2528C) peroxisome proliferator-activated receptor delta gene
25.00 BYN
The gene product regulates lipid and glucose metabolism. The presence of the C allele leads to a decrease in the expression of the PPARA gene and, accordingly, to a decrease in the utilization of fatty acids. The C allele is associated with higher cholesterol levels, which is a risk factor for the development of atherosclerosis and coronary heart disease.

PPARD (+294T/C) peroxisome proliferator-activated receptor delta gene
25.00 BYN
The gene product is the transcriptional coactivator of a number of nuclear receptors, and by way of affecting them, it influences fatty acid oxidation, glucose utilization, thermogenesis, and angiogenesis. Genotypes C/C and C/T are associated with higher levels of low-density lipoproteins, which is a risk factor of atherosclerosis and coronary heart disease development.

PPARGC1A (G1564A) nuclear receptor coactivator PPAR
25.00 BYN
The gene product is a transcriptional coactivator of a number of nuclear receptors, and by way of exerting an effect on them, it influences fatty acid oxidation, glucose utilization, thermogenesis, angiogenesis and muscle fiber transformation. The allele A is associated with a decreased gene activity, the decreased intensity of oxidative processes and mitochondrial biogenesis in cells, decreased insulin sensitivity and a higher obesity risk.

UCP3 (-55C/T) uncoupling protein 3
25.00 BYN
The UCP3 protein plays an important role in thermoregulation, the transport of fatty acids and glucose homeostasis maintenance. The UCP3 T allele is associated with high fatty acid utilization, a lower body mass index, lower fat deposition and an increased level of high-density lipoproteins.

APOE (Cys112Arg; Arg158Cys) apolipoprotein E gen
50.00 BYN
The APOE gene encodes the amino acid sequence of the apolipoprotein E protein, which plays an important role in lipid metabolism. In people with the E2 allele, the conversion of intermediate-density proteins into low-density proteins is impaired due to the ineffective binding of ApoE2 to corresponding receptors. Carriers of at least one of E4 alleles who lead a sedentary lifestyle tend to have increased both total cholesterol, low-density lipoprotein cholesterol (“bad” cholesterol) and triglyceride levels. High-intensity training can normalize a blood lipid profile and increase “good” cholesterol levels. Atherosclerosis is more likely to develop in people with the E2/E2 phenotype, as well as those with at least one E4 allele. Where two E4 copies are present, the risk is higher than in the case of one E4 copy (the risk of cardiovascular diseases’ development is three times higher).

Mandatory services

Mandatory service
4 BYN
Registration, escorting. Collection of biological material (buccal epithelium) of a person.

Mandatory service
14 BYN
Isolation of deoxyribonucleic acid (DNA) from a test sample.

Mandatory service
12 BYN
Development of a genetic passport based on the genetic testing results of your booked order.

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