DNA diagnostics of caffeine metabolism efficiency

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Caffeine

Coffee contains caffeine, which has a vasoconstrictive property. An overdose of caffeine may lead to the excessive stimulation of the central nervous system (“caffeine intoxication”) and provoke increased excitability, irritability, insomnia, and heart rhythm disturbances. Caffeine increases the excretion of calcium from the body, which may cause a decrease in bone strength, as well as vitamin B1 (thiamine); increases blood glucose levels and accelerates the absorption of carbohydrates.

Individual susceptibility

The caffeine sensitivity and metabolism (exchange) rate are different in people and it depends, among other things, on genetic factors. The permissible (harmless) amount of caffeine per day is associated with the individual genetic characteristics of a person. The main enzyme that metabolizes caffeine is cytochrome CYP1A2 ― it decomposes up to 95% of this substance.

Popularity & Dangers

Coffee is one of the most popular drinks across the globe. Coffee trees are grown in more than 50 countries. The largest coffee producer is Brazil. Every year, up to 2.25 billion cups of coffee are consumed in the world. Scandinavian countries (Finland, Norway, Iceland and the Netherlands) are the leaders among the countries with the highest coffee consumption across the globe. On average, one adult there consumes 5 cups of the drink per day. Frequent caffeine consumption together with insufficient water intake contributes to chronic dehydration, which causes the premature aging of organs. Coffee increases the risk of addictive behavior, including addiction to sweets.

Genetic testing fees

FULL

65 ^BYN

Testing of 2 genes
Professor’s conclusion

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Offer a chance for genetic testing!!!. A gift certificate is a great and valuable thing!!! For more details, please contact us by phone.

FAQs

Is special preparation required before providing test material?

No, it is not necessary. There is no need to follow a diet or perform any other special actions before providing material for testing. Taking medications, alcohol etc. will not affect genetic testing results either.

How soon will test results be ready?

Up to 35 working days from the date of signing an agreement. In fact, much sooner: 2-3 weeks.

What do I need to have with me to submit material for testing?

You should have your passport and money on you. Minors must be accompanied by an adult.

What are your working hours?

Our working hours for clients with a booked appointment and providing test results.
On working days: Monday ‒ Thursday, from 9:00 till 17:30; on Fridays: from 9:00 till 16:30.
Days off: Saturday & Sunday.

What biological material is collected for testing and how?

For testing, buccal epithelium (epithelium of the inner part of your cheeks) is collected with a special cotton swab. It is done by a client himself or herself in the presence of a laboratory diagnostics doctor. Blood is not collected.

Can I send biological material for testing by post?

Yes, it is possible. Please follow the link for detailed instructions. The test results can be received in hard copy by mail to your home directly. Where DNA cannot be isolated from the sample provided, you will need to reimburse the cost of the reagents used.

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License

License of the Ministry of Health of the Republic of Belarus for the right to provide medical services of June 17, 2011, No. 02040/6875

Certificate

Certificate of the Reference Institute for Bioanalytics, Bonn, Germany (Referenzinstitut für Bioanalytik, Bonn, Deutschland) issued on April 3, 2021

Functions of the studied genes

CYP1A2 (C/T rs2472297) cytochrome P450 family 1 subfamily A member 2
25.00 BYN
The gene is responsible for the synthesis of the CYP1A2 enzyme, a member of the cytochrome P450 superfamily. Different variants of the cytochrome CYP1A2 enzyme determined by the polymorphism (variation) of the CYP1A2 gene have different activities and caffeine metabolism occurs at a higher or lower rate. In people with low CYP1A2 enzyme activity (slow metabolism), caffeine acts more strongly and lasts longer, which increases the likelihood of side effects. In people with high CYP1A2 enzyme activity, the effect of caffeine is short-lived, which allows consuming more drinks/products containing caffeine without any harm to your health. The polymorphic variant rs762551 leads to increased enzyme activity and accelerated caffeine metabolism. Genotypes T/T and G/T ― fast caffeine metabolism; and G/G ― slow caffeine metabolism.

AHR (A/G rs4410790) aryl hydrocarbon receptor gene
25.00 BYN
The AHR gene controls how much of cytochrome CYP1A2 and cytochrome CYP1A1 enzymes will be produced in your body. The AHR gene, along with the CYP1A2 gene, determines the amount of caffeine that circulates in your blood and its exposure time. If you metabolize caffeine quickly, caffeine does not retain long enough to significantly affect your brain centers, so you can consume more caffeine-containing products. But if your body produces a small amount of the enzyme, the caffeine will stay in your system longer and may cause adverse side effects. The G/G genotype ― the fast caffeine metabolizer; and A/A and G/A ― slow caffeine metabolizers.

Mandatory services

Mandatory service
4 BYN
Registration, escorting. Collection of biological material (buccal epithelium) of a person.

Mandatory service
14 BYN
Isolation of deoxyribonucleic acid (DNA) from a test sample.

Mandatory service
12 BYN
Development of a genetic passport based on the genetic testing results of your booked order.

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