DNA diagnostics for a predisposition to thrombosis and hypertensive crises

To prevent the development of dangerous side effects caused by coronavirus is possible!

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Preventing side effects!

Diseases caused by COVID-19, even mild and even asymptomatic, are dangerous due to their side effects, especially such as thrombosis, hypertensive crisis etc. The development of these side effects can be prevented if you determine your genetic predisposition to these pathologies beforehand.

How will it help?

Genetic testing data will allow you to consult a doctor and, if necessary, implement preventive measures. For example, if there is a high risk of thrombus formation, a doctor will prescribe you antiplatelet and/or anticoagulant drugs; and if there is a hypertensive crisis threat ‒ medications that improve the rheological properties of blood.

Genetic testing fees

Testing of arterial pressure genes

171 ^BYN

Testing of 7 blood pressure regulation genes
Professor's conclusion

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Testing of thrombus formation (hemostasis) genes

185 ^BYN

Testing of 11 thrombus formation genes
Professor's conclusion

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The full complex of genes

331^BYN

Testing of 11 thrombus formation genes
Testing of 7 blood pressure regulation genes
Professor's conclusion

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Offer a chance for genetic testing!!!. A gift certificate is a great and valuable thing!!! For more details, please contact us by phone.

FAQs

Is special preparation required before providing test material?

No, it is not necessary. There is no need to follow a diet or perform any other special actions before providing material for testing. Taking medications, alcohol etc. will not affect genetic testing results either.

How soon will test results be ready?

Up to 35 working days from the date of signing an agreement. In fact, much sooner: 2-3 weeks.

What do I need to have with me to submit material for testing?

You should have your passport and money on you. Minors must be accompanied by an adult.

What are your working hours?

Our working hours for clients with a booked appointment and providing test results.
On working days: Monday ‒ Thursday, from 9:00 till 17:30; on Fridays: from 9:00 till 16:30.
Days off: Saturday & Sunday.

What biological material is collected for testing and how?

For testing, buccal epithelium (epithelium of the inner part of your cheeks) is collected with a special cotton swab. It is done by a client himself or herself in the presence of a laboratory diagnostics doctor. Blood is not collected.

Can I send biological material for testing by post?

Yes, it is possible. Please follow the link for detailed instructions. The test results can be received in hard copy by mail to your home directly. Where DNA cannot be isolated from the sample provided, you will need to reimburse the cost of the reagents used.

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Accreditation

The Certificate of Conformity to STB ISO 9001-2015 No. BY/112 05.01. 077.01 00132 valid till December 3, 2026

License

License of the Ministry of Health of the Republic of Belarus for the right to provide medical services of June 17, 2011, No. 02040/6875

Certificate

Certificate of the Reference Institute for Bioanalytics, Bonn, Germany (Referenzinstitut für Bioanalytik, Bonn, Deutschland) issued on April 3, 2021

Functions of the studied genes

Blood pressure regulation genes

eNOS (4a/4b) endothelial nitric oxide synthase gene
16.00 BYN
It encodes an enzyme that determines the nitric oxide level in the wall of blood vessels. The allele 4a is associated with arterial hypertension, the decreased elasticity of the vascular wall and myocardial hypertrophy.

eNOS (G894T) endothelial nitric oxide synthase gene
25.00 BYN
It encodes an enzyme that determines a nitric oxide level in the wall of blood vessels; the T allele is associated with low endothelial nitric oxide synthase activity, the risk of cardiovascular diseases’ development and high cardiac output during exercise.

PPARD (+294T/C) peroxisome proliferator-activated receptor delta gene
25.00 BYN
The gene product is the transcriptional coactivator of a number of nuclear receptors, and by way of affecting them, it influences fatty acid oxidation, glucose utilization, thermogenesis, and angiogenesis. Genotypes C/C and C/T are associated with higher levels of low-density lipoproteins, which is a risk factor of atherosclerosis and coronary heart disease development

PPARGC1A (G1564A) nuclear receptor coactivator PPAR
25.00 BYN
The allele A is a predisposition factor to cardiovascular diseases (atherosclerosis, hypertension and ischemia), as well as a risk factor of arterial hypertension in individuals with diabetes mellitus.

ACE (Alu Ins/Del) angiotensin-converting enzyme gene
16.00 BYN
The gene is associated with the regulation of blood pressure, maintenance of water-salt homeostasis, and it identifies the risk of a number of cardiovascular pathologies. The D allele carriers have higher levels of ACE activity in plasma, in the heart muscle and in tissues, which may cause the development of coronary heart disease, myocardial infarction, post-infarction complications and arterial hypertension.

APOE (Cys112Arg; Arg158Cys) apolipoprotein E gen
50.00 BYN
It encodes a protein that plays a key role in lipid metabolism, including cholesterol; it is associated with lipid deposition in blood vessels. The presence of the E2 allele of the APOE gene is characterized by the increased levels of cholesterol and triglycerides in blood. Atherosclerosis is more likely to develop in people with the E2/E2 phenotype, as well as those with at least one of E4 alleles. Where two E4 copies are present, the risk is higher than in the case of one E4 copy (the risk of cardiovascular diseases’ development is three times higher).

AGTR1 (А1166С) angiotensin II type 1 receptor gene
25.00 BYN
The substitution of adenine (A) for cytosine (C) affects the functional activity of the angiotensin II type 1 receptor. Such changes may cause alterations in the proliferation of elements through the vascular wall, affect the regulation of vessel lumen and lead to their obstruction.

Hemostasis system genes

F1 (Thr312Ala) coagulation factor I gene
12.50 BYN
Blood coagulation factor I regulates the last stage of the coagulation cascade and influences the formation of a white thrombus. The Ala allele is associated with the risk of cardiovascular diseases’ emergence.

F13 (Val34Leu) coagulation factor XIII gene
12.50 BYN
It is a thrombin activated protein responsible for the stabilization of a fibrin thrombus. The Leu allele is protective and reduces the risk of thrombus formation.

F2 (G20210А) coagulation factor II gene — prothrombin
12.50 BYN
It is one of the main factors of the blood coagulation system. The presence of the “risk” allele A increases a prothrombin level in plasma by 30%; it increases the risk of venous thrombosis, ischemic stroke and thromboembolism (three-fold).

F5 (Arg506Gln) coagulation factor V gene. Leiden mutation
12.50 BYN
The gene product is responsible for the conversion of prothrombin into the active thrombin enzyme. The risk allele A «-» can be the basis for the development of the thrombosis of lower extremities’ veins and the cerebral vessels, an arterial thrombosis at a young age and an ischemic stroke. The heterozygous carriage is associated with a 2-7-fold increase of thrombosis risk; homozygous carriage – with a 40-80-fold increase.

F7 (G10976A) coagulation factor VII gene — proconvertin
25.00 BYN
When the proconvertin level decreases, the formation of thrombin, which catalyzes the conversion of fibrinogen into fibrin with the subsequent clot formation and the stop of bleeding, slows down. In the case of the carriage of the F7 gene A/A allelic variant, proconvertin effects are eliminated, and bleeding becomes systemic.

F11 (T/C rs2036914) coagulation factor XI gene
12.50 BYN
The gene encodes the blood coagulation factor and is involved in the coagulation cascade by activating factor F9. An important function of FXI is to inhibit fibrinolysis by stimulating the production of thrombin activatable fibrinolysis inhibitor. The C allele is associated with deep vein thrombosis risk.

F11 (C/T rs2289252) coagulation factor XI gene
12.50 BYN
The gene encodes the blood coagulation factor 11 and is involved in the coagulation cascade by activating factor F9. The T allele is associated with the risk of various thromboses development.

FGG (C10034T) fibrinogen gamma chain
25.00 BYN
The FGG gene encodes fibrinogen gamma chain, which is one of three peptides forming fibrinogen subunits. Mutations in the FGG gene result in the impaired gamma chain synthesis, which is characterized by a complete absence of fibrinogen or its partial decrease in blood and leads to impaired blood clotting. The T allele is associated with the risk of venous thrombosis development.

ITGB3 (T1565C) integrin beta 3 binding protein
25.00 BYN
It is responsible for the interaction of platelets on the surface of which it is located with blood plasma fibrinogen, which leads to platelet aggregation and thrombus formation. Platelets of C allele carriers have an increased tendency to aggregation, which increases the risk of thrombus formation.

ITGA2 (C807T) integrin subunit alpha 2
25.00 BYN
The ITGA2 gene encodes the alpha-2-membrane glycoprotein protein; ensures the interaction of platelets with the damaged vascular wall, which is a necessary condition for the inclusion of subsequent links in the blood coagulation system. The presence of the T allele is associated with an increase in the rate of platelet adhesion, which may be a risk factor for thrombophilia.

GP1BA (-5T>С) glycoprotein Ib platelet subunit
25.00 BYN
The polymorphism manifests itself as a single nucleotide substitution of thymine (T) for cytosine (C) in the untranslated region of the GP1BA gene, resulting in the amino acid substitution of Val28Ala. The C allele, by increasing the GP1B expression on the platelet surface, increases the risk of thrombus formation in the arterial bed.

Mandatory services

Mandatory service
4 BYN
Registration, escorting. Collection of biological material (buccal epithelium) of a person.

Mandatory service
14 BYN
Isolation of deoxyribonucleic acid (DNA) from a test sample.

Mandatory service
12 BYN
Development of a genetic passport based on the genetic testing results of your booked order.

- The genes marked with this symbol cannot be selected for testing separately from each other. Please contact us by phone for details.

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