DNA diagnostics for a predisposition to high sporting achievements

Identifying sprinter’s or stayer’s abilities, sports aptitude genes and gene variants unfavourable for sports.

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Perspective direction

One of the most promising directions of genetics in sports is the study of relationships between the sporting achievements and the genes responsible for the development and control of functions required for perfection in sports (sports genetics). Different gene variants may affect such qualities as speed, strength and endurance. The most important hereditary factors required to achieve high sporting results include genes that determine cardiovascular system and oxygen metabolism functions.

Hereditary factors

Hereditary factors that ensure rapid and adequate responses to physical activity have been identified, including genes that regulate angiogenesis, vasomotor control, energy metabolism, erythropoiesis, myoglobin synthesis and anabolic processes. The study of polymorphic markers of these genes can significantly advance the selection and training of athletes.

How will it help me?

The genetic testing of athletes (sports genetics) will provide valuable assistance to doctors and team coaches not only in the selection of the most promising athletes, but also in providing each of them with the conditions required to achieve high sporting results.

Why is it important?

The identification of undesirable gene variants that determine the increased or decreased levels of production of certain enzymes allows the correction of such effects in elite athletes using individual medical and biological support.

Genetic testing fees

Identification of sprinter’s or stayer’s abilities

224 ^BYN

Testing of 11 genes determining sprinter’s or stayer’s abilities
Professor's conclusion

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Identification of athletic talent genes and gene variants that are unfavorable for sports

165 ^BYN

Testing of 4 sports aptitude genes
Testing of 2 gene variants that are unfavorable for sports
Professor's conclusion

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The full complex of genes

364 ^BYN

Testing of 11 genes determining sprinter’s or stayer’s abilities
Testing of 4 sports aptitude genes
Testing of 2 gene variants that are unfavorable for sports
Professor's conclusion

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Offer a chance for genetic testing!!!. A gift certificate is a great and valuable thing!!! For more details, please contact us by phone.

FAQs

Is special preparation required before providing test material?

No, it is not necessary. There is no need to follow a diet or perform any other special actions before providing material for testing. Taking medications, alcohol etc. will not affect genetic testing results either.

How soon will test results be ready?

Up to 35 working days from the date of signing an agreement. In fact, much sooner: 2-3 weeks.

What do I need to have with me to submit material for testing?

You should have your passport and money on you. Minors must be accompanied by an adult.

What are your working hours?

Our working hours for clients with a booked appointment and providing test results.
On working days: Monday ‒ Thursday, from 9:00 till 17:30; on Fridays: from 9:00 till 16:30.
Days off: Saturday & Sunday.

What biological material is collected for testing and how?

For testing, buccal epithelium (epithelium of the inner part of your cheeks) is collected with a special cotton swab. It is done by a client himself or herself in the presence of a laboratory diagnostics doctor. Blood is not collected.

Can I send biological material for testing by post?

Yes, it is possible. Please follow the link for detailed instructions. The test results can be received in hard copy by mail to your home directly. Where DNA cannot be isolated from the sample provided, you will need to reimburse the cost of the reagents used.

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Accreditation

The Certificate of Conformity to STB ISO 9001-2015 No. BY/112 05.01. 077.01 00132 valid till December 3, 2026

License

License of the Ministry of Health of the Republic of Belarus for the right to provide medical services of June 17, 2011, No. 02040/6875

Certificate

Certificate of the Reference Institute for Bioanalytics, Bonn, Germany (Referenzinstitut für Bioanalytik, Bonn, Deutschland) issued on April 3, 2021

Functions of the studied genes

ACTN3 (R577X)
25.00 BYN

Determining sprinter’s or stayer’s abilities

BDKRB2 (I/D) bradykinin β2 receptor gene
16.00 BYN
It is one of the main mediators of the bradykinin effect reducing vascular tone and promoting smooth muscle contraction. The presence of the D allele is associated with high gene expression, a more pronounced vasodilatory effect and a predisposition to endurance.

eNOS (4a/4b) endothelial nitric oxide synthase gene
16.00 BYN
It encodes an enzyme that determines the nitric oxide level in the wall of blood vessels. The allele 4b is associated with endurance; the allele 4a is associated with arterial hypertension, the decreased elasticity of the vascular wall and myocardial hypertrophy.

HIF1A (C1772T) hypoxia-inducible factor
25.00 BYN
A transcription factor that ensures body’s adaptation to hypoxia: it activates the expression of genes that regulate the process of angiogenesis, vasomotor control, energy metabolism, erythropoiesis and apoptosis. The T allele is associated with human speed and strength qualities.

PPARA (G2528C) peroxisome proliferator-activated receptor delta gene
25.00 BYN
The gene product regulates energy homeostasis. The presence of the G allele is associated with the normal utilization of fatty acids and glucose, and the C allele leads to a decrease in the PPARA expression and, accordingly, to a decrease in muscular endurance. The G allele is associated with endurance and the C allele with speed/strength.

PPARD (+294T/C) peroxisome proliferator-activated receptor delta gene
25.00 BYN
The gene product is involved in muscle tissue, as well as fat and carbohydrate metabolism. The C allele carriers are characterized by increased gene activity, which ensures the more intensive oxidation of fatty acids and, accordingly, higher endurance, especially in combination with the G/G variant of the PPARGC1A gene. The C allele carriers predominantly have slow-twitch muscle fibers. The C allele is associated with endurance.

PPARG (Pro12Ala) peroxisome proliferator-activated receptor gamma
25.00 BYN
The product regulates the activity of genes responsible for carbohydrate and fat metabolism. The presence of the Ala allele increases the body's sensitivity to insulin and enhances its anabolic effect on skeletal muscles. Thus, the PPARG Ala allele carriers are more predisposed to speed/strength sports compared the Pro allele carriers since their muscles utilize glucose to a greater extent. Ala is the speed/strength allele.

PPARGC1A (G1564A) nuclear receptor coactivator PPAR
25.00 BYN
The coactivator of nuclear receptors of PPAR family genes and estrogen is involved in fatty acid oxidation, glucose utilization, thermogenesis, angiogenesis and muscle fiber transformation. The allele A of the PPARGC1A gene is associated with speed/strength qualities in humans.

UCP2 (Ala55Val) uncoupling protein
25.00 BYN
The Val allele is associated with the high metabolic efficiency of muscle and physical activity, reduced energy expenditure at rest, the low utilization of fatty acids and the risk of type 2 diabetes and obesity development. The Val/Val homozygote carriers must be highly physically active throughout their lives; otherwise there is a risk of metabolic disorders’ development. The Val allele is associated with endurance; and Ala is the allele of speed and strength.

UCP3 (-55C/T) uncoupling protein 3
25.00 BYN
The UCP3 protein plays an important role in thermoregulation, the transport of fatty acids and glucose levels maintenance. The T allele of the UCP3 gene is associated with high aerobic capacity and high performance. The T allele is associated with endurance.

ACE (Alu Ins/Del) angiotensin-converting enzyme gene
16.00 BYN
The gene is associated with the regulation of blood pressure, maintaining water-salt homeostasis, and is responsible for the body's susceptibility to a particular type of physical activity. The I/I genotype determines 7-8 times higher physical performance compared to the D/D genotype. I is the endurance allele; D is the speed and strength allele.

Determining athletic aptitude genes

EPO (G3876T) erythropoietin receptor gene
25.00 BYN
It is one of the most important factors of erythropoiesis and new blood vessels’ development. It mediates erythropoietin activity. The genotype T/T increases resistance to physical exertion by 7.5 times.

MB (A79G) myoglobin gene
25.00 BYN
The iron-containing protein of muscle cells — an analogue of red blood cells’ hemoglobin. The myoglobin gene is responsible for the transport of oxygen in skeletal muscles and in the heart muscle; the storage (deposition) of molecular oxygen and its transfer to the oxidative systems of cells.

VEGF (G-634C) vascular endothelial growth factor A
25.00 BYN
VEGF plays a central role in the formation of new and the survival of immature blood vessels, thereby improving muscle blood flow and promoting an increase in muscle growth after exercise. The C allele is associated with better exercise performance: a greater increase in maximal oxygen uptake in response to aerobic exercise.

PAI-1 (4G/5G) plasminogen activator inhibitor-1
25.00 BYN
One of the main components of the thrombolytic plasminogen-plasmin system. It regulates fibrinolysis. The 4G allele carriage leads to an increased gene expression and, consequently, to the increased PAI-1 level in blood, which leads to decreased fibrinolysis and the formation of a fibrin base for the growth of new blood vessels. The carriers of the PAI-1 gene 4G/4G genotype are characterized by a more significant increase in maximum oxygen consumption in response to physical exercise, training endurance, versus 5G/5G genotype carriers.

Determining gene variants unfavourable for sports

AMPD1 (C34T) adenosine monophosphate deaminase 1 gene
25.00 BYN
The C/C genotype is characterized by the normal activity of adenosine monophosphate. C/T and T/T genotype carriers are characterized by decreased enzyme activity, which indicates slow recovery after highly intensive physical exercise.

APOE (Cys112Arg; Arg158Cys) apolipoprotein E gen
50.00 BYN
Apolipoprotein E regulates the transfer of cholesterol between tissues and plasma. There are three main alleles the products of which are designated as E2, E3 and E4. For the carriers of the risk allele E4 of the APOE gene, it is not recommended to take up sports associated with the risk of head injury (boxing, taekwondo, karate etc.). This recommendation is due to a genetic predisposition to the development of brain diseases (neurodegenerative).

Mandatory services

Mandatory service
4 BYN
Registration, escorting. Collection of biological material (buccal epithelium) of a person.

Mandatory service
14 BYN
Isolation of deoxyribonucleic acid (DNA) from a test sample.

Mandatory service
12 BYN
Development of a genetic passport based on the genetic testing results of your booked order.

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