DNA diagnostics for a predisposition to metabolic syndrome

Including the testing of genes that control the feeling of satiety as a result of food intake (eating behavior)

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Global issue

WHO experts consider metabolic syndrome (MS) a new pandemic of the 21st century affecting industrialized countries. The prevalence of metabolic syndrome is twice as high as diabetes mellitus, and its growth rate is expected to increase by 50% in the next 25 years. According to modern concepts, metabolic syndrome is a cluster of hormonal and metabolic disorders, cardiovascular diseases, obesity and diabetes mellitus. The development of metabolic syndrome is determined by a complex interaction of hereditary and environmental risk factors. The most important environmental factors contributing to the development of metabolic syndrome are the excessive consumption of food containing fats and sugars and low physical activity leading to overweight and obesity.

It’s dangerous!

According to WHO, about 30% of the world's population is overweight. Obese people are 50% more likely to develop hypertension than people with normal body weight. A number of studies have found a direct proportional relationship between the body weight and the overall mortality ‒ it has been established that with weight gain, cardiovascular diseases boost, including the risk of coronary heart disease, myocardial infarction, sudden death and stroke. In addition, 1st degree obesity increases the risk of type 2 diabetes three-fold; in the case of 2nd degree obesity ‒ by 5 times; and 3rd degree obesity ‒ by 10 times.

Important to note!

It is important to note that the majority of patients with metabolic syndrome are people of active working age constituting the most productive and significant layer of society. In addition, over the past two decades, the syndrome under study has demonstrated a steady increase among young people and children.

What is the result?

The most important thing in the prevention and treatment of metabolic syndrome is proper nutrition, increased physical activity, giving up bad habits, i.e. the formation of a healthy lifestyle. The effectiveness of such measures has been proven by numerous international study results. The identification of allelic gene variants that determine the increased genetic risk of metabolic syndrome development will make it possible to implement effective preventive measures for this disease, as well as correctly choose the methods of its treatment, significantly improve its prognosis and avoid possible side effects.

Genetic testing fees

FULL

305 ^BYN

Testing of 13 genes predisposing to metabolic syndrome, including 2 genes controlling the feeling of satiety as a result of food intake
Professor's conclusion

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Offer a chance for genetic testing!!!. A gift certificate is a great and valuable thing!!! For more details, please contact us by phone.

FAQs

Is special preparation required before providing test material?

No, it is not necessary. There is no need to follow a diet or perform any other special actions before providing material for testing. Taking medications, alcohol etc. will not affect genetic testing results either.

How soon will test results be ready?

Up to 35 working days from the date of signing an agreement. In fact, much sooner: 2-3 weeks.

What do I need to have with me to submit material for testing?

You should have your passport and money on you. Minors must be accompanied by an adult.

What are your working hours?

Our working hours for clients with a booked appointment and providing test results.
On working days: Monday ‒ Thursday, from 9:00 till 17:30; on Fridays: from 9:00 till 16:30.
Days off: Saturday & Sunday.

What biological material is collected for testing and how?

For testing, buccal epithelium (epithelium of the inner part of your cheeks) is collected with a special cotton swab. It is done by a client himself or herself in the presence of a laboratory diagnostics doctor. Blood is not collected.

Can I send biological material for testing by post?

Yes, it is possible. Please follow the link for detailed instructions. The test results can be received in hard copy by mail to your home directly. Where DNA cannot be isolated from the sample provided, you will need to reimburse the cost of the reagents used.

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Accreditation

The Certificate of Conformity to STB ISO 9001-2015 No. BY/112 05.01. 077.01 00132 valid till December 3, 2026

License

License of the Ministry of Health of the Republic of Belarus for the right to provide medical services of June 17, 2011, No. 02040/6875

Certificate

Certificate of the Reference Institute for Bioanalytics, Bonn, Germany (Referenzinstitut für Bioanalytik, Bonn, Deutschland) issued on April 3, 2021

Functions of the studied genes

PPARA (G2528C) peroxisome proliferator-activated receptor delta gene
25.00 BYN
The gene product regulates energy homeostasis. The presence of the G allele is associated with the normal utilization of fatty acids and glucose, and the C allele leads to a decrease in PPARA expression and, accordingly, to a decrease in fatty acid oxidation and an increase in glucose utilization.

PPARD (+294T/C) peroxisome proliferator-activated receptor delta gene
25.00 BYN
The gene product is involved in muscle tissue, as well as fat and carbohydrate metabolism. The C allele carriers are characterized by increased gene activity, which ensures the more intensive oxidation of fatty acids and, accordingly, higher endurance, especially in combination with the G/G variant of the PPARGC1A gene. The C allele carriers are characterized by a lower body mass index and lower subcutaneous fat content.

PPARG (Pro12Ala) peroxisome proliferator-activated receptor gamma
25.00 BYN
The PPARG gene product is synthesized in adipose tissue, activates the proliferation of organelles that oxidize fatty acids and controls the differentiation of fat cells. The Ala allele is associated with a reduced predisposition to excess body weight and produces a protective effect against the growth of fat cells.

PPARGC1A (G1564A) nuclear receptor coactivator PPAR
25.00 BYN
The gene product is a transcriptional coactivator of a number of nuclear receptors, and by way of exerting an effect on them, it influences fatty acid oxidation, glucose utilization, thermogenesis, angiogenesis and muscle fiber transformation. The allele A is associated with a decreased gene activity, the decreased intensity of oxidative processes and mitochondrial biogenesis in cells, decreased insulin sensitivity and a higher obesity risk.

UCP2 (Ala55Val) uncoupling protein
25.00 BYN
The Val allele is associated with the high metabolic efficiency of muscle and physical activity, reduced energy expenditure at rest and the low utilization of fatty acids. The Val/Val homozygote carriers must be highly physically active throughout their lives; otherwise there is a risk of metabolic disorders’ development.

UCP3 (-55C/T) uncoupling protein 3
25.00 BYN
The UCP3 protein plays an important role in thermoregulation, the transport of fatty acids and glucose homeostasis maintenance. The UCP3 T allele is associated with high fatty acid utilization, a lower body mass index, lower fat deposition and an increased level of high-density lipoproteins.

APOE (Cys112Arg; Arg158Cys) apolipoprotein E gen
50.00 BYN
The APOE gene encodes the amino acid sequence of the apolipoprotein E protein, which plays an important role in lipid metabolism. In people with the E2 allele, the conversion of intermediate-density proteins into low-density proteins is impaired due to the ineffective binding of ApoE2 to corresponding receptors. Carriers of at least one of E4 alleles who lead a sedentary lifestyle tend to have increased both total cholesterol, low-density lipoprotein cholesterol (“bad” cholesterol) and triglyceride levels. High-intensity training makes it possible to normalize a blood lipid profile and increase a “good” cholesterol level.

ADIPOQ (+276G > T) adiponectin
25.00 BYN
The ADIPOQ gene product (adiponectin) is a hormone secreted by white adipose tissue. The level of adiponectin in blood plasma is inversely proportional to the mass of adipose tissue and the waist-to-hip ratio (WHR). The -11391A allele carriers are characterized by lower weight and waist-to-hip ratio. The carriers of G/T and T/T genotypes of the polymorphic variant +276G>T are characterized by a higher obesity risk.

GNB3 (С825Т) G protein subunit beta 3
25.00 BYN
The GNB3 gene product is a G protein that is involved in the transmission of information from receptors to intracellular executive systems. It is part of the signaling pathways of many hormones (including insulin and neurotransmitters). The T allele is associated with the risk of hypertension, increased body mass index (BMI), obesity, diabetes and atherosclerosis development.

LEP (G(-2548)A) leptin
25.00 BYN
The product of the LEP gene is leptin involved in the regulation of depot fat volume regulating food intake and energy expenditure. In obese people, the level of serum leptin is usually increased, and the relationship between the body weight and the serum leptin is linear. The presence of the G allele is associated with a change in leptin secretion, which causes an increase in body weight and, as a consequence, various pathologies associated with obesity.

ADIPOQ (-11391 G/A) adiponectin
25.00 BYN
Adiponectin has a protective function against hyperglycemia, insulin resistance and atherosclerosis. The -11391A allele carriers are characterized by a lower weight and waist-to-hip ratio. The risk of obesity in people with the A/A genotype is lower compared to G/G. The G/A genotype is also associated with a lower obesity risk.

Genes that control the feeling of satiety as a result of food intake (eating behavior)

FTO (c.IVS1 A>T) alpha-ketoglutarate-dependent dioxygenase
25.00 BYN
The allele A carriers have increased indicators associated with obesity: the FTO gene A/A homozygote carriage indicates that the amount of FTO protein in the body is significantly reduced, and, as a result, a delayed feeling of satiety is typical. The above variant carriers, compared to the T/T genotype carries, on average, consume 280 kcal more per day, and are more likely to suffer from obesity by 8 times. The A/A genotype carriers are recommended to monitor the amount of food consumed and take up sport. Physical activity helps neutralize a negative A allele effect.

MC4R (T>C) melanocortin 4 receptor
25.00 BYN
Melanocortin is a polypeptide with hormonal activity, which is produced in pituitary gland and acts as a satiety signal. Changes in the sequence of the gene encoding the melanocortin 4 receptor lead to the body not receiving a signal of sufficient energy accumulation, and, as a result, a need for more frequent food intake arises.

Mandatory services

Mandatory service
4 BYN
Registration, escorting. Collection of biological material (buccal epithelium) of a person.

Mandatory service
14 BYN
Isolation of deoxyribonucleic acid (DNA) from a test sample.

Mandatory service
12 BYN
Development of a genetic passport based on the genetic testing results of your booked order.

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