COMT (472G>A) (catechol-O-methyltransferase gene)

The gene is present in the following complexes:

DNA diagnostics of a person’s psycho-emotional status

The COMT gene encodes catechol-ortho-methyltransferase, a key dopamine enzyme. The allele A of the COMT gene is characterized by lower enzymatic activity, and therefore, by a higher dopamine level. The A allele carriers are characterized by an increased predisposition to stress and various obsessive states compared to G allele carriers, which is associated with a higher COMT enzyme activity, and therefore, with a normal dopamine level and higher stress resistance.