FTO (c.IVS1 A>T) (alpha-ketoglutarate-dependent dioxygenase)

The gene is present in the following complexes:

Testing of genes that determine effective weight loss as a result of physical exercise

In the fat tissue of the FTO gene A/A genotype carriers, there is no effective initiation of lipolysis and a decrease in the amount of fat tissue in the body in response to physical activity. It was shown that in this genotype carriers, who had been actively taking up sports for 20 weeks, a decrease in the mass of fat tissue was 40 times lower compared to the C/C homozygote carriers. People with the FTO gene A/A genotype need significantly higher levels of physical activity and a low-calorie diet to lose weight.

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DNA diagnostics for a predisposition to metabolic syndrome

The allele A carriers have increased indicators associated with obesity: the FTO gene A/A homozygote carriage indicates that the amount of FTO protein in the body is significantly reduced, and, as a result, a delayed feeling of satiety is typical. The above variant carriers, compared to the T/T genotype carries, on average, consume 280 kcal more per day, and are more likely to suffer from obesity by 8 times. The A/A genotype carriers are recommended to monitor the amount of food consumed and take up sport. Physical activity helps neutralize a negative A allele effect.

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