DNA diagnostics for a predisposition to pregnancy loss
The enzyme directly remethylates homocysteine. The nucleotide substitution of A for G is accompanied by a disruption of homocysteine remethylation, which leads to its increased level in blood plasma. Hyperhomocysteinemia increases the likelihood of thrombosis and can lead to premature placental abruption, preeclampsia and the termination of pregnancy. The adverse effects of this gene may be corrected by the additional intake of vitamin B12.