DNA diagnostics for a predisposition to pregnancy loss
When the proconvertin level decreases, the formation of thrombin, which catalyzes the conversion of fibrinogen into fibrin with subsequent clot formation and bleeding cessation, slows down. In the case of the F7 gene AA genotype carriage, proconvertin effects are eliminated and bleeding becomes systemic. The presence of a heterozygous variant of the F7 gene polymorphism in a woman can lead to chorionic detachment in the first trimester of pregnancy.