F11 (T/C rs2036914) (coagulation factor XI gene)

The gene is present in the following complexes:

DNA diagnostics for a predisposition to pregnancy loss

The gene encodes the blood coagulation factor 11 and is involved in the coagulation cascade by activating factor F9. An important function of FXI is the inhibition of fibrinolysis by stimulating the production of thrombin activatable fibrinolysis inhibitor. The C allele is associated with deep vein thrombosis risk.

DNA diagnostics for a predisposition to thrombosis and hypertensive crises

The gene encodes the blood coagulation factor and is involved in the coagulation cascade by activating factor F9. An important function of FXI is to inhibit fibrinolysis by stimulating the production of thrombin activatable fibrinolysis inhibitor. The C allele is associated with deep vein thrombosis risk.