The D allele carriers are characterized by the higher levels of angiotensin II activity — one of the most powerful biologically active substances increasing blood pressure. The D allele is found in women with habitual miscarriage and pregnancy complications (placental insufficiency, gestosis etc.).
The gene is associated with the regulation of blood pressure, maintenance of water-salt homeostasis, and it identifies the risk of a number of cardiovascular pathologies. The D allele carriers have higher levels of ACE activity in plasma, in the heart muscle and in tissues, which may cause the development of coronary heart disease, myocardial infarction, post-infarction complications and arterial hypertension.
The gene is associated with the regulation of blood pressure, maintenance of water-salt homeostasis, and it identifies the risk of a number of cardiovascular pathologies. The D allele carriers have higher levels of ACE activity in plasma, in the heart muscle and in tissues, which may cause the development of coronary heart disease, myocardial infarction, post-infarction complications and arterial hypertension.
The gene is associated with the regulation of blood pressure, maintaining water-salt homeostasis, and is responsible for the body's susceptibility to a particular type of physical activity. The I/I genotype determines 7-8 times higher physical performance compared to the D/D genotype. I is the endurance allele; D is the speed and strength allele.