PPARA (G2528C) (peroxisome proliferator-activated receptor delta gene)

DNA diagnostics for a predisposition to type 2 diabetes

The gene product regulates lipid and glucose metabolism. The presence of the C allele leads to a decrease in the expression of the PPARA gene, which reduces the utilization of fatty acids, affects tissue sensitivity to insulin and the functioning of pancreatic beta cells. As a result, the risk of type 2 diabetes increases by 2.7 times. For patients with type 2 diabetes, the presence of the C allele in the genotype also increases the risk of cardiovascular diseases’ development.

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DNA diagnostics for a predisposition to hypercholesterolemia

The gene product regulates lipid and glucose metabolism. The presence of the C allele leads to a decrease in the expression of the PPARA gene and, accordingly, to a decrease in the utilization of fatty acids. The C allele is associated with higher cholesterol levels, which is a risk factor for the development of atherosclerosis and coronary heart disease.

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DNA diagnostics for a predisposition to metabolic syndrome

The gene product regulates energy homeostasis. The presence of the G allele is associated with the normal utilization of fatty acids and glucose, and the C allele leads to a decrease in PPARA expression and, accordingly, to a decrease in fatty acid oxidation and an increase in glucose utilization.

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DNA diagnostics for a predisposition to high sporting achievements

The gene product regulates energy homeostasis. The presence of the G allele is associated with the normal utilization of fatty acids and glucose, and the C allele leads to a decrease in the PPARA expression and, accordingly, to a decrease in muscular endurance. The G allele is associated with endurance and the C allele with speed/strength.

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