The gene product is a transcriptional coactivator of a number of nuclear receptors, and by way of affecting them, it influences fatty acid oxidation, glucose utilization, thermogenesis and angiogenesis. Genotypes C/C and C/T are associated with a higher level of low-density lipoproteins, which is a risk factor of atherosclerosis and pregnancy pathology development; in particular, it causes fetal growth restriction.
The gene product is involved in muscle tissue, as well as fat and carbohydrate metabolism. The C allele carriers are characterized by increased gene activity resulting in more intensive oxidation of fatty acids.
The gene product is the transcriptional coactivator of a number of nuclear receptors, and by way of affecting them, it influences fatty acid oxidation, glucose utilization, thermogenesis, and angiogenesis. Genotypes C/C and C/T are associated with higher levels of low-density lipoproteins, which is a risk factor of atherosclerosis and coronary heart disease development
The gene product is the transcriptional coactivator of a number of nuclear receptors, and by way of affecting them, it influences fatty acid oxidation, glucose utilization, thermogenesis, and angiogenesis. Genotypes C/C and C/T are associated with higher levels of low-density lipoproteins, which is a risk factor of atherosclerosis and coronary heart disease development.
The gene product is involved in muscle tissue, as well as fat and carbohydrate metabolism. The C allele carriers are characterized by increased gene activity, which ensures the more intensive oxidation of fatty acids and, accordingly, higher endurance, especially in combination with the G/G variant of the PPARGC1A gene. The C allele carriers are characterized by a lower body mass index and lower subcutaneous fat content.
The gene product is involved in muscle tissue, as well as fat and carbohydrate metabolism. The C allele carriers are characterized by increased gene activity, which ensures the more intensive oxidation of fatty acids and, accordingly, higher endurance, especially in combination with the G/G variant of the PPARGC1A gene. The C allele carriers predominantly have slow-twitch muscle fibers. The C allele is associated with endurance.