The APOE protein is an enzyme that plays an important role in lipid metabolism. The carriers of E1, E2 and E4 alleles are predisposed to lipid metabolism, circulatory disorders, as well as pregnancy loss.
The APOE gene encodes the amino acid sequence of apolipoprotein E (a protein), which plays an important role in lipid metabolism. People who carry at least one E4 or E2 allele and leading a sedentary lifestyle tend to have increased total cholesterol, low-density lipoprotein cholesterol (“bad” cholesterol) and triglyceride levels. High-intensity physical training makes it possible to normalize a blood lipid profile and increase a “good” cholesterol level.
It encodes a protein that plays a key role in lipid metabolism, including cholesterol; it is associated with lipid deposition in blood vessels. The presence of the E2 allele of the APOE gene is characterized by the increased levels of cholesterol and triglycerides in blood. Atherosclerosis is more likely to develop in people with the E2/E2 phenotype, as well as those with at least one of E4 alleles. Where two E4 copies are present, the risk is higher than in the case of one E4 copy (the risk of cardiovascular diseases’ development is three times higher).
It encodes a protein that plays a key role in lipid metabolism, including cholesterol; it is associated with lipid deposition in blood vessels. The presence of the E2 allele of the APOE gene is characterized by the increased levels of cholesterol and triglycerides in blood. Atherosclerosis is more likely to develop in people with the E2/E2 phenotype, as well as those with at least one of E4 alleles. Where two E4 copies are present, the risk is higher than in the case of one E4 copy (the risk of cardiovascular diseases’ development is three times higher).
The APOE gene encodes the amino acid sequence of the apolipoprotein E protein, which plays an important role in lipid metabolism. In people with the E2 allele, the conversion of intermediate-density proteins into low-density proteins is impaired due to the ineffective binding of ApoE2 to corresponding receptors. Carriers of at least one of E4 alleles who lead a sedentary lifestyle tend to have increased both total cholesterol, low-density lipoprotein cholesterol (“bad” cholesterol) and triglyceride levels. High-intensity training can normalize a blood lipid profile and increase “good” cholesterol levels. Atherosclerosis is more likely to develop in people with the E2/E2 phenotype, as well as those with at least one E4 allele. Where two E4 copies are present, the risk is higher than in the case of one E4 copy (the risk of cardiovascular diseases’ development is three times higher).
The APOE gene encodes the amino acid sequence of the apolipoprotein E protein, which plays an important role in lipid metabolism. In people with the E2 allele, the conversion of intermediate-density proteins into low-density proteins is impaired due to the ineffective binding of ApoE2 to corresponding receptors. Carriers of at least one of E4 alleles who lead a sedentary lifestyle tend to have increased total cholesterol, low-density lipoprotein cholesterol (“bad” cholesterol) and triglyceride levels. High-intensity training makes it possible to normalize a blood lipid profile and increase a “good” cholesterol level.
Apolipoprotein E regulates the transfer of cholesterol between tissues and plasma. There are three main alleles the products of which are designated as E2, E3 and E4. For the carriers of the risk allele E4 of the APOE gene, it is not recommended to take up sports associated with the risk of head injury (boxing, taekwondo, karate etc.). This recommendation is due to a genetic predisposition to the development of brain diseases (neurodegenerative).