The A/A genotype in combination with the Pro/Pro genotype of the PPARG gene is an undoubtful predictor of the transition of impaired glucose tolerance to type 2 diabetes. The A allele indicates a predisposition to type 2 diabetes (it increases the risk by 1.9 times).
The gene product determines fat and carbohydrate metabolism. The allele A is associated with a decreased gene activity and the decreased intensity of oxidative processes and mitochondrial biogenesis in cells. A reliable increase in the prevalence of genotypes with the variant allele A of the PPARGC1A gene in a group of patients indicates that fat and carbohydrate metabolism during pregnancy is disturbed and the development of placental insufficiency happens causing fetal growth restriction.
The gene product is a transcriptional coactivator of a number of nuclear receptors, and by way of exerting an effect on them, it influences fatty acid oxidation, glucose utilization, thermogenesis, angiogenesis and muscle fiber transformation. The allele A is associated with decreased gene activity, the decreased intensity of oxidative processes and mitochondrial biogenesis in cells and decreased insulin sensitivity.
The allele A is a predisposition factor to cardiovascular diseases (atherosclerosis, hypertension and ischemia), as well as a risk factor of arterial hypertension in individuals with diabetes mellitus.
The gene product is a transcriptional coactivator of a number of nuclear receptors, and by way of exerting an effect on them, it influences fatty acid oxidation, glucose utilization, thermogenesis, angiogenesis and muscle fiber transformation. The allele A is associated with a decreased gene activity, the decreased intensity of oxidative processes and mitochondrial biogenesis in cells, decreased insulin sensitivity and a higher obesity risk.
The gene product is a transcriptional coactivator of a number of nuclear receptors, and by way of exerting an effect on them, it influences fatty acid oxidation, glucose utilization, thermogenesis, angiogenesis and muscle fiber transformation. The allele A is associated with a decreased gene activity, the decreased intensity of oxidative processes and mitochondrial biogenesis in cells, decreased insulin sensitivity and a higher obesity risk.
The coactivator of nuclear receptors of PPAR family genes and estrogen is involved in fatty acid oxidation, glucose utilization, thermogenesis, angiogenesis and muscle fiber transformation. The allele A of the PPARGC1A gene is associated with speed/strength qualities in humans.